What Happens When You Take Psychedelics: The Neuroscience, Clinical Research, and Mechanism of Action
Psychedelics are not random noise in the brain — they are precise pharmacological tools with a defined mechanism: 5-HT2A receptor agonism that dissolves the default mode network and flattens the brain's predictive hierarchy. The MAPS Phase 3 MDMA trials, Johns Hopkins psilocybin studies, and Carhart-Harris's REBUS model explain why they work.